Implications of flavonoids as potential modulators of cancer neovascularity

摘要: The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling physiological processes and various pathologies including cancer. Despite that, the development anti-angiogenic drugs has great potential as treatment cancer faces many problems such resistance to an improperly selected therapy approach. An evaluation predictive markers personalized medicine could significantly improve outcomes patients. This comprehensive review emphasizes anticancer flavonoids mediated by their efficacy evaluated current preclinical clinical research. Flavonoids are important groups phytochemicals present common diet. show significant effects. effects currently a widely discussed topic able regulate process tumor angiogenesis through modulation signaling molecules VEGF, MMPs, ILs, HIF others. However, within studies not frequently still scientific interest.