Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
作者： Napoleone Ferrara , Kenneth J Hillan , Hans-Peter Gerber , William Novotny , None
DOI: 10.1038/NRD1381
关键词: Vascular endothelial growth factor 、 Blood vessel 、 Angiogenesis 、 Cancer 、 Antibody 、 Monoclonal 、 Colorectal cancer 、 Medicine 、 Bevacizumab 、 Immunology 、 Cancer research
摘要: … In 1993, it was shown that a monoclonal antibody that targeted VEGF results in a … the development of bevacizumab (Avastin; Genentech), a humanized variant of this anti-VEGF antibody…
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