Monoclonal Antibodies as Therapeutic Agents

摘要: Monoclonal antibodies are effective targeted therapeutic agents. The high specificity of the makes them ideal to reach their intended target and thus is useful treat a variety disease states. This chapter begins with an explanation methods which used propagate isolate monoclonal antibodies. There description hybridoma technology, CDR grafting, phage display technology. These techniques develop various antibodies, including chimeric, humanized, human followed by specific as drugs diseases autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus, Crohn’s disease, multiple sclerosis), immune system-mediated (psoriasis), transplant rejection, thrombosis, cancer, allergic well others. Immunoconjugates comprised antibody linked chemotherapeutic agent or source(s) radiation discussed cancer. treatment cancer includes both hematologic malignancies solid tumors. each identified along its precise mechanism action, clinical use, adverse effects.