Vascular Endothelial Growth Factor Receptors
作者： K.A. Thomas
DOI: 10.1016/B978-0-12-378630-2.00359-5
关键词: Cancer research 、 Growth factor 、 Angiogenesis 、 Tyrosine kinase 、 Biology 、 Vascular endothelial growth factor B 、 Vascular endothelial growth factor 、 Vascular endothelial growth factor C 、 Receptor tyrosine kinase 、 Signal transduction 、 Cell biology
摘要: Vascular endothelial growth factor receptors (VEGFRs) are a set of three homologous transmembrane receptor tyrosine kinases that bind vascular factors (VEGFs). VEGFRs expressed throughout the and lymphatic systems by some cells immune nervous systems. Dimeric VEGF binding to VEGFR extracellular domains promotes dimerization mutual subunit transphosphorylation intracellular domains. Specific proteins these phosphotyrosine residues initiating signaling cascade culminates in cellular migration, mitosis, survival promoting blood vessels, respectively, termed ‘angiogenesis’ ‘lymphangiogenesis’. Alternative splicing generates soluble can sequester ligands inhibit activation.
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