Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways.

摘要: Invasion and metastasis are among the main causes of death in patients with malignant tumors. Fisetin (3,3',4',7-tetrahydroxyflavone), a natural flavonoid found smoke tree (Cotinus coggygria), is known to have antimetastatic effects on prostate lung cancers; however, effect fisetin breast cancer unknown. The aim this study was determine anti-invasive activity human cells. Matrix metalloproteinase (MMP)-9 major component facilitating invasion many tumor cell types, thus inhibitory MMP-9 expression 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated cells investigated study. significantly attenuated TPA-induced MCF-7 cells, inhibit activation PKCα/ROS/ERK1/2 p38 MAPK signaling pathways. This furthermore associated reduced NF-κB activation, suggesting that may result from inhibited TPA signals, ultimately leading downregulation expression. Our findings indicate role invasion, clarify underlying molecular mechanisms role, as potential chemopreventive agent for metastasis.