Age-Related Changes in Frontal Network Structural and Functional Connectivity in Relation to Bimanual Movement Control

摘要: Changes in both brain structure and neurophysiological function regulating homotopic as well heterotopic interhemispheric interactions (IHIs) are assumed to be responsible for the bimanual performance deficits older adults. However, how structural functional networks decline adults, interplay between remain largely unclear. Using a dual-site transcranial magnetic stimulation paradigm, we examined age-related changes effects from dorsolateral prefrontal cortex dorsal premotor onto contralateral primary motor (M1) during preparation of complex coordination task human. Structural properties these were assessed with diffusion-based fiber tractography. Compared young adults showed declines more difficult conditions, less optimal white matter (WM) microstructure, decreased ability regulate interaction M1. Importantly, found that WM function, interrelated whereas only task-related IHI predicted These results reflect unique aging brain, such microstructural organization likely lead dysfunctional regulation IHI, ultimately accounting deficits. SIGNIFICANCE STATEMENT The associated movement control, compromising independence. We used MRI noninvasive techniques investigate relation control. modulations resulted poor By interrelating structure, behavior, current study provides comprehensive picture biological alterations underlie performance.