Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians.

摘要: Increased serum uric acid (SUA) or hyperuricemia, a risk factor for gout, renal and cardiovascular diseases, is caused by either increased production decreased excretion of mix both. The solute carrier protein 2 family, member 9 (SLC2A9) gene encodes transporter that mediates urate flux across the proximal tubule. Genome-wide association studies have consistently shown single-nucleotide polymorphisms in this with SUA majority populations. American Indian participants Strong Heart Family Study, belonging to multigenerational families, high prevalence hyperuricemia. We conducted measured genotype analyses, based on variance components decomposition method accounting family relationships, assess whether between SLC2A9 generalized Indians (n=3604) study. Seven were selected genotyping their levels other A strong was found all centers combined (P-values: 1.3 × 10−31–5.1 10−23) also when stratified recruitment center; P-values: 1.2 10−14–1.0 10−5. These associated estimated glomerular filtration rate creatinine but not albumin–creatinine ratio. In summary, extends new population Indians.