Genetic influence on variation in serum uric acid in American Indians: the strong heart family study
作者： V. Saroja Voruganti , Harald H. H. Göring , Amy Mottl , Nora Franceschini , Karin Haack
DOI: 10.1007/S00439-009-0716-8
关键词:
摘要: Hyperuricemia is associated with the metabolic syndrome, gout, renal and cardiovascular disease (CVD). American Indians have high rates of CVD 25% individuals in strong heart family study (SHFS) serum uric acid levels. The aim this was to investigate genetic determinants variation Indian participants SHFS. A variance component decomposition approach (implemented SOLAR) used conduct univariate analyses each three centers combined sample. Serum adjusted for age, sex, age x BMI, estimated glomerular filtration rate, alcohol intake, diabetic status medications. Overall mean +/- SD all 5.14 1.5 mg/dl. found be significantly heritable (0.46 0.03 centers, 0.39 0.07, 0.51 0.05, 0.44 0.06 Arizona, Dakotas Oklahoma, respectively). Multipoint linkage analysis showed significant evidence on chromosome 11 center [logarithm odds score (LOD) = 3.02] sample (LOD 3.56) 1 3.51) positional candidate gene region solute carrier family22, member 12 (SLC22A12) that encodes a major transporter URAT1. These results show influence possible role one or more genes chromosomes populations.
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