Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma
作者： Yoshinari Shinsato , Tatsuhiko Furukawa , Shunji Yunoue , Hajime Yonezawa , Kentarou Minami
关键词: DNA mismatch repair 、 O-6-methylguanine-DNA methyltransferase 、 MutL Protein Homolog 1 、 MLH1 、 PMS2 、 Biology 、 Cancer research 、 DNA repair 、 Neoplasm 、 Temozolomide
摘要: Although there is a relationship between DNA repair deficiency and temozolomide (TMZ) resistance in glioblastoma (GBM), it remains unclear which molecule associated with GBM recurrence. We isolated three TMZ-resistant human cell lines examined the expression of O6-methylguanine-DNA methyltransferase (MGMT) mismatch (MMR) components. used immunohistochemical analysis to compare MutL homolog 1 (MLH1), postmeiotic segregation increased 2 (PMS2) MGMT primary recurrent specimens obtained from patients during TMZ treatment. found reduction MLH1 subsequent PMS2 protein levels cells. Furthermore, or knockdown confered resistance. In tumours, was reduced when compared tumours.
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