Death receptor 5 and neuroproliferation.

摘要: Tumor necrosis factor-related apoptosis-inducing ligand or Apo2 is a member of the tumor factor superfamily cytokines that induces apoptosis upon binding to its death domain-containing transmembrane receptors, receptors 4 and 5 (DR4, DR5). However, DR5 also expressed in developing CNS where it appears play role unrelated apoptosis, instead may be involved regulation neurogenesis. We report on distribution expression mouse hippocampus, cerebellum, rostral migratory stream (RMS) olfactory bulb from embryonic (E) day 16 (E16) postnatal (P) (P180). At E16, DR5-positive cells were distributed widely hippocampus with strong immunostaining dentate gyrus. In newborn predominantly located proliferative zones, such as gyrus, subventricular zone, RMS. After 7 (P7), number decreased, intense fluorescence primarily restricted subgranular layer (SGL), although granular cell showed weak fluorescence. P30, only few found SGL, mature granule negative for expression. To address whether progenitor neurons, we performed 5-bromo-deoxyuridine labeling. SGL selectively express DR5, lower levels positive doublecortin, marker neurons. addition, stem intestine, RMS demonstrated DR5-positive. meantime, glial fibrillary acidic protein, Bergmann cells. conclude by neuroprogenitor suggesting receptor likely key neuroproliferation differentiation.