Epidemiology and outcome of candidaemia in patients with oncological and haematological malignancies: results from a population-based surveillance in Spain

摘要: Abstract A prospective, population-based surveillance on candidaemia was implemented in five metropolitan areas of Spain from May 2010 to April 2011. We aimed describe the distribution and susceptibility pattern Candida species, evaluate risk factors for mortality patients with oncological (solid tumours) haematological malignancies. Adults (≥16 years) cancer were included present report. Impact therapeutic strategies 7- 30-day analysed by logistic regression, adjusting propensity score inverse weighting probability receiving early antifungal treatment catheter removal. 238 (32.6%) (195 oncological, 43 haematological). Compared patients, more likely have received chemotherapy (53.5% versus 17.4%, p  albicans species (71.1% 55.6%, p 0.056) tropicalis (22.2% 7.6%, 0.011) frequent patients. Based EUCAST breakpoints, 27.6% isolates non-susceptible fluconazole. Resistance echinocandins negligible. Mortality at 7 30 days 12.2% 31.5%, respectively, did not differ significantly between patient groups. Prompt therapy together removal (≤48 hours) associated lower (adjusted OR 0.05; 95% CI 0.01–0.42) 0.27; 0.16–0.46). In conclusion, non- are emerging as predominant isolates, particularly Prompt, adequate plus may lead a reduction mortality.