A prospective, cohort, multicentre study of candidaemia in hospitalized adult patients with haematological malignancies

摘要: Invasive candidiasis is a life-threatening infection in patients with haematological malignancies. The objective of our study was to determine the incidence, microbiological characteristics and clinical outcome candidaemia among hospitalized adult This population-based, prospective, multicentre ≥ 18 years admitted haematology and/or haematopoietic stem cell transplantation units nine tertiary care Greek hospitals from January 2009 through February 2012. Within this cohort, we conducted nested case-control risk factors for candidaemia. Stepwise logistic regression used identify independent predictors 28-day mortality. Candidaemia detected 40 27,864 malignancies vs. 967 1,158,018 non-haematology an incidence 1.4 cases/1000 admissions 0.83/1000 respectively (p <0.001). caused predominantly (35/40, 87.5%) by non-Candida albicans species, particularly Candida parapsilosis (20/40, 50%). In vitro resistance at least one antifungal agent observed 27% isolates. Twenty-one (53%) developed breakthrough while receiving agents. Central venous catheters, hypogammaglobulinaemia high APACHE II score were development Crude mortality day 28 greater those than control cases (18/40 (45%) 9/80 (11%); p <0.0001). conclusion, despite prophylaxis, relatively frequent associated non-C. spp., especially C. parapsilosis. catheters are that provide potential targets improving outcome.