Clinical and molecular characteristics of bloodstream infections caused by Candida albicans in children from 2003 to 2011

摘要: We investigated the clinical and molecular characteristics of Candida albicans bloodstream infection (BSI) in children from a tertiary-level medical centre Taiwan over 9-year period January 2003 to December 2011. performed multilocus sequence typing (MLST) investigate genetic relatedness these C. BSI isolates. A total 79 episodes 76 paediatric patients were identified, including 41 (51.9%) intensive care unit, 24 (30.4%) neonatal unit 14 (17.7%) general wards. More than half (59.5%) had underlying chronic co-morbidities, majority (94.9%) catheter or some other artificial device. All isolates susceptible antifungal agents tested. Only 32.9% (26/79) received effective within h onset candidaemia. Twenty-five (31.6%) persistent candidaemia (>3 days after start treatment) candidaemia-attributable mortality rate was 22.8% (18/79). The 72 available for MLST yielded 53 unique diploid types (DSTs). Forty-five DSTs singletons eight shared by 27 (37.5%) Seventy-one (98.6%) clustered previously known clades. Based on definition two more strains with DST occurring 90 days, 10.1% infections categorized as nosocomial clusters, most commonly identified units. Although cluster-associated not associated higher rate, none clusters hospital control team.