Factors and outcomes associated with candidemia caused by non-albicans Candida spp versus Candida albicans in children

作者: Wei-Ju Lee , Jen-Fu Hsu , Mei-Yin Lai , Ming-Chou Chiang , Han-Chen Lin

DOI: 10.1016/J.AJIC.2018.05.015

关键词: MedicineInternal medicineRisk factorConfidence intervalMortality rateFluconazoleCentral venous catheterCandida albicansLogistic regressionOdds ratio

摘要: Background Candidemia in children caused by non-albicans Candida (NAC) spp is increasing prevalence, but the relevant information limited. Methods All isolates of pediatric candidemia from a medical center Taiwan between 2003 and 2015 were enrolled. The characteristics patients with NAC albicans (CAC) compared. Results Among 319 episodes occurring 262 patients, C accounted for 46.4%. CAC groups had no significant differences demographics, underlying diseases, most risk factors, clinical characteristics. Patients group significantly more likely to have fluconazole exposure (14.0% vs 6.8%, respectively; P = .045), species 70.2% all recurrent episodes. longer duration (median, 3.0 1.0 days after effective antifungal treatment, P = .001), slower responses higher rate treatment failure than CAC. However, 2 similar 30-day candidemia-attributable mortality rates. After multivariate logistic regression, central venous catheter was independent factor (odds ratio, 1.21; 95% confidence interval, 1.08-1.35 every 10-day increment). Conclusions collectively emerged as predominant pathogens children. Prolonged use associated an increased species.

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