Risk of resistance associated with fluconazole prophylaxis: systematic review.
作者： Luc P. Brion , Smart E. Uko , David L. Goldman
DOI: 10.1016/J.JINF.2006.11.017
关键词:
摘要: Summary Background Several studies have shown that fluconazole prophylaxis reduces the risk of fungal colonization and invasive infection in high-risk patients with minimal toxicity. This systematic review was designed to estimate emergence either azole susceptible-dose dependent or resistant strains. Methods We searched Medline, EMBASE, Cochrane Collaboration database our own files for randomized controlled trials assessing effect on incidence fluconazole-resistant Results clinical shows increases yeasts, percentage non- albicans Candida isolates isolates. Fluconazole did not significantly affect disease fungi. The sample size too small assess breakthrough infections . Conclusion Evidence from suggests fungi, but does remains a concern needs be addressed large prospective studies.
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