Fluconazole-resistant Candida: Mechanisms and risk factor identification
作者： MarkAlain Déry , Rodrigo Hasbun
DOI: 10.1007/S12281-010-0045-3
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摘要: The extensive use of fluconazole in the previous two decades has fostered emergence azole-resistant strains, including non-albicans species such as C. glabrata. main mechanisms resistance described involve alteration quality or quantity 14-alpha-demethylase enzyme reduced access drug to target by upregulation efflux pumps. Fluconazole prophylaxis been used successfully prevent fungal infections high-risk neonates, neutropenic patients, individuals with HIV infection, recipients solid organ (eg, liver) transplants and bone marrow transplants, patients intensive care units, a small increase risk colonization, but not fluconazole-resistant Candida isolates. Among other factors, recent exposure is associated candidemia.
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