Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system.
作者： Haruhiro Higashida , Alla B. Salmina , Raissa Ya Olovyannikova , Minako Hashii , Shigeru Yokoyama
DOI: 10.1016/J.NEUINT.2007.06.023
关键词: Signal transduction 、 Cell biology 、 Neurotransmitter receptor 、 CD38 、 ADP-ribosyl Cyclase 、 Biochemistry 、 Cyclase 、 Cyclase activity 、 Cyclic ADP-ribose 、 Ryanodine receptor 、 Biology
摘要: β-NAD+ is as abundant ATP in neuronal cells. functions not only a coenzyme but also substrate. β-NAD+-utilizing enzymes are involved signal transduction. We focus on ADP-ribosyl cyclase/CD38 which synthesizes cyclic ADP-ribose (cADPR), universal Ca2+ mobilizer from intracellular stores, β-NAD+. cADPR acts through activation/modulation of ryanodine receptor releasing channels. synthesis cells stimulated or modulated via different pathways and various factors. Subtype-specific coupling neurotransmitter receptors with cyclase confirms the involvement enzyme transduction neurons glial Moreover, cADPR/CD38 critical oxytocin release hypothalamic cell dendrites nerve terminals posterior pituitary. Therefore, it possible that pharmacological manipulation levels activity synthetic analogues may provide new therapeutic opportunities for treatment neurodevelopmental disorders.
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