TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis
作者： Honghong Sun , Shunyou Gong , Ruaidhri J. Carmody , Anja Hilliard , Li Li
DOI: 10.1016/J.CELL.2008.03.026
关键词: Immune receptor 、 Immune system 、 Biology 、 Immunity 、 Acquired immune system 、 Immunology 、 T-cell receptor 、 Tumor necrosis factor alpha 、 Innate lymphoid cell 、 Inflammation
摘要: Immune homeostasis is essential for the normal functioning of immune system, and its breakdown leads to fatal inflammatory diseases. We report here identification a member tumor necrosis factor-α-induced protein-8 (TNFAIP8) family, designated TIPE2, that required maintaining homeostasis. TIPE2 preferentially expressed in lymphoid tissues, deletion mice multiorgan inflammation, splenomegaly, premature death. TIPE2-deficient animals are hypersensitive septic shock, cells hyper-responsive Toll-like receptor (TLR) T cell (TCR) activation. Importantly, binds caspase-8 inhibits activating protein-1 nuclear factor-κB activation while promoting Fas-induced apoptosis. Inhibiting significantly blocks hyper-responsiveness cells. These results establish an negative regulator TLR TCR function, selective expression system prevents hyperresponsiveness maintains
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