The Central Role for Microenvironment in B-Cell Malignancies: Recent Insights into Synergistic Effects of its Therapeutic Targeting and Anti-CD20 Antibodies.

摘要: Most B-cell-related disorders can be cured with conventional agents; however, relapse is common, creating a need for additional therapeutic options. In agreement, recent biomarker studies corroborate the role played by functional crosstalk between malignant B cells and microenvironment which have added texture to clinical outcome. Here we outline essential of tumor-associated niche in B-cell Lymphoma/Leukemia pathogenesis, an attempt optimize use microenvironment-targeted drugs anti-CD20 antibodies various subsets.