Clinical Significance of sIL-2R Levels in B-Cell Lymphomas
作者： Noriaki Yoshida , Miyo Oda , Yoshiaki Kuroda , Yuta Katayama , Yoshiko Okikawa
DOI: 10.1371/JOURNAL.PONE.0078730
关键词:
摘要: Elevated soluble interleukin-2 receptor (sIL-2R) in sera is observed patients with malignant lymphoma (ML). Therefore, sIL-2R commonly used as a diagnostic and prognostic marker for ML, but the mechanisms responsible increase levels B-cell lymphomas have not yet been elucidated. We first hypothesized that cells expressing IL-2R some proteinases such matrix metalloproteinases (MMPs) tumor microenvironment can give rise to increased sera. However, flow cytometric studies revealed few expressed α chain (CD25) diffuse large (DLBCL) follicular (FL), most CD25-expressing were T-cells. Distinct correlations between CD25 expression on B-lymphoma observed. then confirmed MMP-9 plays an important role producing functional studies. Immunohistochemical (IHC) analysis also mainly derived from tumor-associated macrophages (TAMs). therefore evaluated number of CD68 CD163 positive using IHC analysis. A correlation numbers was FL extranodal DLBCL. These results may be useful understanding pathophysiology lymphomas.
core.ac.uk
harvard.edu
sci-hub.se 参考文章(38)
Jeffrey W. Pollard, Tumour-educated macrophages promote tumour progression and metastasis Nature Reviews Cancer. ,vol. 4, pp. 71- 78 ,(2004) , 10.1038/NRC1256
W E Biddison, R Yarchoan, L A Rubin, D L Nelson, C C Kurman, B Boutin, M E Fritz, Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. Journal of Immunology. ,vol. 135, pp. 3172- 3177 ,(1985)
N. El Houda Agueznay, C. Badoual, S. Hans, A. Gey, B. Vingert, S. Peyrard, F. Quintin-Colonna, P. Ravel, P. Bruneval, S. Roncelin, B. Lelongt, J. Bertoglio, W. H. Fridman, D. Brasnu, E. Tartour, Soluble interleukin‐2 receptor and metalloproteinase‐9 expression in head and neck cancer: prognostic value and analysis of their relationships Clinical and Experimental Immunology. ,vol. 150, pp. 114- 123 ,(2007) , 10.1111/J.1365-2249.2007.03464.X
Achille Ambrosetti, Gianpaolo Nadali, Fabrizio Vinante, Maria Maddalena Ricetti, Giuseppe Todeschini, Lorella Morosato, Donata de Sabata, Ivo Andrea Bergamo Andreis, Marco Chilosi, Gianpietro Semenzato, Giovanni Pizzolo, Soluble interleukin-2 receptor in hairy-cell leukemia: a reliable marker of disease International Journal of Clinical & Laboratory Research. ,vol. 23, pp. 34- 37 ,(1993) , 10.1007/BF02592278
Massimo Federico, Monica Bellei, Luigi Marcheselli, Stefano Luminari, Armando Lopez-Guillermo, Umberto Vitolo, Barbara Pro, Stefano Pileri, Alessandro Pulsoni, Pierre Soubeyran, Sergio Cortelazzo, Giovanni Martinelli, Maurizio Martelli, Luigi Rigacci, Luca Arcaini, Francesco Di Raimondo, Francesco Merli, Elena Sabattini, Peter McLaughlin, Philippe Solal-Céligny, None, Follicular Lymphoma International Prognostic Index 2: A New Prognostic Index for Follicular Lymphoma Developed by the International Follicular Lymphoma Prognostic Factor Project Journal of Clinical Oncology. ,vol. 27, pp. 4555- 4562 ,(2009) , 10.1200/JCO.2008.21.3991
Toshihisa Hayashibara, Yasuaki Yamada, Yasuyuki Onimaru, Chizuko Tsutsumi, Susumu Nakayama, Naoki Mori, Takayuki Miyanishi, Shimeru Kamihira, Masao Tomonaga, Tetsuo Maita, Matrix metalloproteinase-9 and vascular endothelial growth factor: a possible link in adult T-cell leukaemia cell invasion British Journal of Haematology. ,vol. 116, pp. 94- 102 ,(2002) , 10.1046/J.1365-2141.2002.03255.X
Andreas Rosenwald, George Wright, Wing C. Chan, Joseph M. Connors, Elias Campo, Richard I. Fisher, Randy D. Gascoyne, H. Konrad Muller-Hermelink, Erlend B. Smeland, Jena M. Giltnane, Elaine M. Hurt, Hong Zhao, Lauren Averett, Liming Yang, Wyndham H. Wilson, Elaine S. Jaffe, Richard Simon, Richard D. Klausner, John Powell, Patricia L. Duffey, Dan L. Longo, Timothy C. Greiner, Dennis D. Weisenburger, Warren G. Sanger, Bhavana J. Dave, James C. Lynch, Julie Vose, James O. Armitage, Emilio Montserrat, Armando López-Guillermo, Thomas M. Grogan, Thomas P. Miller, Michel LeBlanc, German Ott, Stein Kvaloy, Jan Delabie, Harald Holte, Peter Krajci, Trond Stokke, Louis M. Staudt, The Use of Molecular Profiling to Predict Survival after Chemotherapy for Diffuse Large-B-Cell Lymphoma The New England Journal of Medicine. ,vol. 346, pp. 1937- 1947 ,(2002) , 10.1056/NEJMOA012914
Luca Arcaini, Michele Merli, Francesco Passamonti, Silvia Rizzi, Virginia Ferretti, Sara Rattotti, Cristiana Pascutto, Marco Paulli, Mario Lazzarino, Validation of follicular lymphoma international prognostic index 2 (FLIPI2) score in an independent series of follicular lymphoma patients British Journal of Haematology. ,vol. 149, pp. 455- 457 ,(2010) , 10.1111/J.1365-2141.2009.08065.X
Laurence A Rubin, Francine Galli, Warner C Greene, David L Nelson, Gilbert Jay, The molecular basis for the generation of the human soluble interleukin 2 receptor Cytokine. ,vol. 2, pp. 330- 336 ,(1990) , 10.1016/1043-4666(90)90062-X
Daisuke Niino, Yoshihiro Komohara, Toshihiko Murayama, Ryosuke Aoki, Yoshizo Kimura, Keiko Hashikawa, Junichi Kiyasu, Masanori Takeuchi, Nobuko Suefuji, Yasuo Sugita, Motohiro Takeya, Koichi Ohshima, Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma (AITL) Pathology International. ,vol. 60, pp. 278- 283 ,(2010) , 10.1111/J.1440-1827.2010.02514.X