The role of tumor-associated macrophages on serum soluble IL-2R levels in B-cell lymphomas.
作者： Akira Sakai , Noriaki Yoshida
DOI: 10.3960/JSLRT.54.49
关键词: IL-2 receptor 、 Cancer research 、 Tumor-associated macrophage 、 B cell 、 CD30 、 Follicular lymphoma 、 Lymphoid hyperplasia 、 Leukemia 、 Lymphoma 、 Biology 、 Immunology
摘要: Interkeukin-2 receptor (IL-2R) is comprised of three different subunits (α, β, and γ chain) expressed on B cells NK besides T cells. CD25 also known as the IL-2Rα chain cell membranes, while soluble IL-2R (sIL-2R) generated by proteolytic cleavage chain. Levels sIL-2R in sera are monitored a marker disease activity patients with lymphoma. However, elevated serum levels found inflammatory diseases, such infectious diseases. thought to reflect tumor burden adult T-cell leukemia/lymphoma due expression Conversely, be mainly derived from activated infiltrating tissues diffuse large B-cell lymphoma (DLBCL) follicular (FL) because except for subtype DLBCL negative CD25. Matrix metalloproteinase-9, protease capable cleaving membrane bound chain, produced tissue-associated macrophages. Increased macrophages reported associated poor prognosis, especially Hodgkin's We increased FL compared reactive lymphoid hyperplasia well positive correlation between number extranodal DLBCL.
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