Epigenetic Priming in Childhood Acute Lymphoblastic Leukemia.

摘要: Leukemogenesis is considered to be a process by which normal cell acquires new but aberrant identity in order disseminate malignant clonal population. Under this setting, the phenotype of leukemic cells identical leukemia-initiating genetic insult taking place. Thus, with some exceptions, B-cell and T-cell childhood leukemias are supposed arise from B- or T-committed cells. In contrast, several recent studies have revealed that alterations may act "hit-and-run" way cell-of-origin imposing tumor giving rise either leukemias. This novel mechanism transformation mediated an epigenetic priming established initial lesion. hit might unnecessary for subsequent evolution conservation, being engine evolution.