International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions.

摘要: Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase activities. Among prostaglandins (PGs), prostacyclin (PGI2) and PGE2 strongly involved in the regulation of homeostasis main physiologic functions. In addition, synthesis these two is significantly increased during inflammation. PGI2 exert their biologic actions by binding to respective receptors, namely receptor (IP) prostaglandin E2 (EP) 1-4, which belong family G-protein-coupled receptors. IP EP1-4 receptors widely distributed body thus play various pathophysiologic roles. this review, we discuss recent advances studies using pharmacological approaches, genetically modified animals, genome-wide association regarding roles immune, cardiovascular, nervous, gastrointestinal, respiratory, genitourinary, musculoskeletal systems. particular, highlight similarities differences between human rodents terms specific downstream signaling pathways, functions, activities for each system. We also potential novel therapeutic benefit targeting several diseases based on scientific advances, animal models, studies. SIGNIFICANCE STATEMENT: present an update role receptor, 1, EP2, EP3, EP4 when activated prostaglandins, E2, produced inflammatory conditions rodents. comparison published results tissue and/or pathology should facilitate choice most appropriate model future