Chromosome aberrations in B-cell chronic lymphocytic leukemia

摘要: Chromosome analyses were performed on leukemic cells from 102 patients with B-CLL, of whom 84 untreated. B-cell mitogen-induced CLL yielded suitable metaphases in 85 patients, and 55 showed clonal chromosomal aberrations. Trisomy 12 was found 26 patients. In nine the + a single aberration. A 14q chromosome or deletions long arm chromosomes 6, 11, 13 other recurrent Patients Rai stage I more had frequently aberrations than 0 disease (p less .02). poorer 5-year survival those normal karyotype .05). high percentage abnormal sample prognosis admixture .01). Of specific trisomy tended to have slightly 6q- structural involving better complex be an adverse prognostic sign. Clonal evolution is rare: karyotypes are at diagnosis clones did not acquire additional despite progressive treatment. Nine hundred seventy-nine published cases reviewed, pathogenetic mechanisms, such as oncogenes gene dosage, discussed.