Independent Predictors of Cognitive Decline in Healthy Elderly Persons

摘要: Background Several studies have shown that individually memory, hippocampal volume, and motor measures presage the onset of dementia. It is unclear if these independently contribute to prediction mild cognitive impairment. Objective To determine ability a gait speed predict decline in healthy elderly persons. Design A prospective, longitudinal, observational cohort study with mean follow-up 6 years. Participants One hundred eight optimally cognitively intact subjects. Main outcome Any impairment noted on Clinical Dementia Rating Scale (score = 0.5) or persistent progressive Cox modeling determined time was associated baseline logical memory II test score (a measure delayed recall), volume (magnetic resonance imaging), (time walk 30 ft [9 m]) independent age, sex, depression, allele producing epsilon4 type apolipoprotein E (APOE epsilon4). Results Questionable dementia occurred 48 participants (SD) 3.7 (2.4) This progressed 38 4.4 Logical performance each predicted questionable dementia, age sex. Time additionally contributed Possessing APOE depression did not enter either model significantly. Conclusions Models combining multiple risk factors should refine impairment, harbingers Individuals at for may represent high-risk group intervention.