Cerebral hypoperfusion is exaggerated with an upright posture in heart failure: impact of depressed cardiac output.

摘要: Abstract Objectives The purpose of this study was to examine cerebral blood flow (CBF) supine and during upright sitting in HF patients control subjects test the hypothesis that with will have a greater reduction CBF from seated compared group. Background Reduced has been reported heart failure (HF). However, previous work has only examined while supine, although an posture common daily living may lead further reductions. Methods In 22 age- sex-matched subjects, continuous rate, mean arterial pressure, end-tidal carbon dioxide readings were collected upright. Cardiac output estimated pulse contour analysis corrected for body size (cardiac index). right internal carotid artery imaged by using ultrasound estimate CBF. Results Heart rate increased less response versus (p = 0.006). Mean pressure unchanged, whereas decreased position (p = 0.004) but did not differ between groups. index lower (p  Conclusions exaggerated increase risk for subsequent cognitive impairment.