Low Cardiac Index Is Associated With Incident Dementia and Alzheimer Disease The Framingham Heart Study

摘要: Background—Cross-sectional epidemiological and clinical research suggests that lower cardiac index is associated with abnormal brain aging, including smaller volumes, increased white matter hyperintensities, worse cognitive performances. Lower systemic blood flow may have implications for dementia among older adults. Methods Results—A total of 1039 Framingham Offspring Cohort participants free stroke, transient ischemic attack, formed our sample (age, 69±6 years; 53% women). Multivariable-adjusted proportional hazard models adjusting Stroke Risk Profile score sex, systolic pressure, antihypertensive medication, diabetes mellitus, cigarette smoking, cardiovascular disease history, atrial fibrillation), education, apolipoprotein E4 status related magnetic resonance imaging–assessed (cardiac output divided by body surface area) to incident all-cause Alzheimer (AD). Over the median 7.7-year follow-...