Effects of Gamma Irradiation on Bone – Clinical Experience

作者: William W. Tomford

DOI: 10.1533/9781845690779.3.133

关键词: Adverse effectIrradiationMusculoskeletal tissueMedicineHigh dosesGamma irradiationSurgeryResistant bacteriaBone strengthBone transplantation

摘要: ABSTRACT The use of radiation for sterilisation musculoskeletal tissue allografts began more than fifty years ago. Based on irradiation vascular tissues, the development as a sterilising method bone has paralleled popularity transplantation. Historical research suggests that at doses 25-30 kGy & minimal adverse effect strength and healing, although effects osteoinductivity are not fully researched. Future may employ high to kill viruses resistant bacteria with pre-treatment grafts.

参考文章(28)
M J Anderson, J H Keyak, H B Skinner, Compressive mechanical properties of human cancellous bone after gamma irradiation. Journal of Bone and Joint Surgery, American Volume. ,vol. 74, pp. 747- 752 ,(1992) , 10.2106/00004623-199274050-00014
Bernard E. Proctor, Samuel A. Goldblith, Electromagnetic Radiation Fundamentals and their Applications in Food Technology Advances in Food Research. ,vol. 3, pp. 119- 196 ,(1951) , 10.1016/S0065-2628(08)60260-8
O. Cornu, X. Banse, P. L. Docquier, S. Luyckx, Ch. Delloye, Effect of freeze-drying and gamma irradiation on the mechanical properties of human cancellous bone. Journal of Orthopaedic Research. ,vol. 18, pp. 426- 431 ,(2000) , 10.1002/JOR.1100180314
J. G. Trump, R. J. Van De Graaff, Irradiation of Biological Materials by High Energy Roentgen Rays and Cathode Rays Journal of Applied Physics. ,vol. 19, pp. 599- 604 ,(1948) , 10.1063/1.1698178
John G. Trump, R. J. van de Graaff, A Compact Pressure-Insulated Electrostatic X-Ray Generator Physical Review. ,vol. 55, pp. 1160- 1165 ,(1939) , 10.1103/PHYSREV.55.1160
Steven A. Lietman, William W. Tomford, Mark C. Gebhardt, Dempsey S. Springfield, Henry J. Mankin, Complications of irradiated allografts in orthopaedic tumor surgery. Clinical Orthopaedics and Related Research. ,vol. 375, pp. 214- 217 ,(2000) , 10.1097/00003086-200006000-00026
JONATHAN COHEN, Cathode Ray Sterilization of Bone Grafts Archives of Surgery. ,vol. 71, pp. 784- 789 ,(1955) , 10.1001/ARCHSURG.1955.01270170142026
ANNA DZIEDZIC-GOCLAWSKA, KAZIMIERZ OSTROWSKI, WACLAW STACHOWICZ, JACEK MICHALIK, WOJCIECH GRZESIK, Effect of radiation sterilization on the osteoinductive properties and the rate of remodeling of bone implants preserved by lyophilization and deep-freezing. Clinical Orthopaedics and Related Research. pp. 30- 37 ,(1991) , 10.1097/00003086-199111000-00006
Cecil G. Dunn, William L. Campbell, Harvey Fram, Ardelia Hutchins, Biological and Photo‐Chemical Effects of High Energy, Electrostatically Produced Roentgen Rays and Cathode Rays Journal of Applied Physics. ,vol. 19, pp. 605- 616 ,(1948) , 10.1063/1.1698179