Human herpesvirus 6 infection and Kawasaki disease.

作者: M Okano , J Luka , G M Thiele , Y Sakiyama , S Matsumoto

DOI: 10.1128/JCM.27.10.2379-2380.1989

关键词: Kawasaki diseaseVirologyImmunoglobulin GAntibody titerImmunoglobulin MImmunologyHerpesviridaeBiologyViral diseaseHuman herpesvirus 6Antibody

摘要: Eighteen of a total 22 serum specimens (81.8%) from patients with Kawasaki disease were positive for immunoglobulin G or M antibodies to human herpesvirus 6, whereas 10 16 age- and sex-matched healthy controls (62.5%) seropositive. Additionally, increased geometric mean antibody titers shown in these patients. These results suggest that the status 6 infection may be reflection immunologic alterations are associated disease.

参考文章(6)
R S Geha, N Wood, D Y Leung, E T Chu, S Grady, R Meade, Immunoregulatory T cell abnormalities in mucocutaneous lymph node syndrome. Journal of Immunology. ,vol. 130, pp. 2002- 2004 ,(1983)
S Zaki Salahuddin, Dharam V Ablashi, Phillip D Markham, Steven F Josephs, Susi Sturzenegger, Mark Kaplan, Gregory Halligan, Peter Biberfeld, Flossie Wong-Staal, Bernhard Kramarsky, Robert C Gallo, None, Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders Science. ,vol. 234, pp. 596- 601 ,(1986) , 10.1126/SCIENCE.2876520
Koichi Yamanishi, Kimiyasu Shiraki, Toshio Kondo, Toshiomi Okuno, Michiaki Takahashi, Yoshizo Asano, Takeshi Kurata, Identification of human herpesvirus-6 as a causal agent for exanthem subitum The Lancet. ,vol. 331, pp. 1065- 1067 ,(1988) , 10.1016/S0140-6736(88)91893-4
JamesC. Niederman, MarkH. Kaplan, Chun-Ren Liu, NathanielA. Brown, CLINICAL AND SEROLOGICAL FEATURES OF HUMAN HERPESVIRUS-6 INFECTION IN THREE ADULTS The Lancet. ,vol. 332, pp. 817- 819 ,(1988) , 10.1016/S0140-6736(88)92783-3
M Okano, G M Thiele, J R Davis, H L Grierson, D T Purtilo, Epstein-Barr virus and human diseases: recent advances in diagnosis. Clinical Microbiology Reviews. ,vol. 1, pp. 300- 312 ,(1988) , 10.1128/CMR.1.3.300
D.V. ABLASHI, S.Z. SALAHUDDIN, S.F. JOSEPHS, F. IMAM, P. LUSSO, R.C. GALLO, C. HUNG, J. LEMP, P.D. MARKHAM, HBLV (orHHV-6) in human cell lines Nature. ,vol. 329, pp. 207- 207 ,(1987) , 10.1038/329207A0