A novel DOPA-albumin based tissue adhesive for internal medical applications

摘要: Abstract To date, existing tissue adhesives have various weak points in gluing kinetics and stability – particularly, biocompatibility, which make most of them remain suboptimal for internal conditions. Herein, a novel mussel-inspired “BCD” glue made bovine serum albumin (BSA), citrate acid (CA) dopamine was developed aiming at medical applications. BSA employed as natural biocompatible macromolecular backbone; CA introduced dual-functional intermediate to increase reactive carboxyl sites engraftment onto backbone also block the competing amines from proteinic backbone. Timely curing stable adhesion were achieved between biological substrates via instant chelation gradual conjugation DOPA-catechol groups BCD glue. Within 30 min, this newly can provide over 10-fold greater stress than that commercially available fibrin wet environment. As adhesive use, its superior properties include ideal gelation swelling behaviour, appropriate degradation rate, sound cytocompatibility in vitro, well fine biocompatibility in vivo. More importantly, successful animal experimentations seroma prevention hemostasis ultimately validated glue's preclinical efficacy