Endothelin-1 induces increased fibronectin expression in human bronchial epithelial cells.

摘要: Endothelin-1 may be involved in the pathogenesis of asthma by causing bronchial smooth muscle constriction and airway remodelling. Bronchial epithelial cells represent an important source endothelin-1 this disease, increased release cell-derived contribute to genesis subepithelial fibrosis promoting fibroblast proliferation collagen production. In study, we demonstrate that upregulates fibronectin gene expression via ETAreceptor. Fibronectin is component extracellular matrix which deposited excess area asthmatic mucosa, it represents a potent chemotactic factor for fibroblasts. Thus, induce both directly autocrine mechanism reported here.