Human Adenovirus Type 5 as a Delivery Vector is Not Neutralized in Field Serum Samples of Cattle, Pig, and Goat of Republic of Korea
作者： Su-Mi Kim , Hyang-Sim Lee , Kwang-Nyeong Lee , Jong-Hyeon Park , Young-Joon Ko
DOI: 10.4167/JBV.2014.44.3.269
关键词: Antibody 、 Titer 、 Virology 、 Livestock 、 Serum samples 、 Biology 、 Virus 、 Neutralizing antibody 、 Transduction (genetics)
摘要: Human adenovirus type 5 (hAd5) vectors have been demonstrated to be useful vehicles for gene expressions in animals. However, it has not reported whether hAd5 transduction might hampered the sera of livestock animals Republic Korea. We collected 205 samples animals, such as pig (n=84), cattle and goat (n=37) The neutralizing antibody (NAb) titers virus were less than 15 most samples. Only 8% had a NAb titer or 30. Thus, we showed that was neutralized from cattle, pig, goat, suggest vector could used effective delivery vaccines proteins field.
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