Membrane Targeting in Secretion

摘要: Regulated secretion and exocytosis require the selective packaging of regulated secretory proteins in storage organelles controlled docking fusion these with plasma membrane. Secretory granule biogenesis involves sorting membrane components both at level trans-Golgi network immature granule. Sorting is thought to be mediated by protein aggregation interaction specific domains. There now considerable interest understanding complex lipid—protein protein—protein interactions A role for lipid microdomains associated receptors targeting formation vividly discussed (neuro)endocrine cells. In exocrine cells, however, little has been known composition function. With cloning characterization their inner leaflet zymogen granules pancreatic acinar it possible elcuidate function zymogens molecular level.