Antiepileptic drug withdrawal after successful surgery for intractable temporal lobe epilepsy.

摘要: Summary: Purpose: To investigate the prognosis related to antiepileptic drug (AED) discontinuation after successful surgery for intractable temporal lobe epilepsy. Methods: The clinical courses lobectomies (TLs) were retrospectively analyzed in 88 consecutive patients. All patients had TLs as only surgical procedure, and they been followed up longer than 3 years. AED was attempted if patient seizure free without aura ≥1 year during follow-up period. Results: Sixty-six (75%) achieved complete freedom year; 28 immediately (immediate success); 38 became some period of recurrent seizures (delayed success). 60 (91%) 66 with a outcome. In 13 (22%) patients, relapse developed reduction (n = 60), seven (12%) AEDs 38). recurrence rate not different between immediate- delayed-success groups. Among 20 tapering, nine (45%) them regained reinstitution treatment, eventually discontinued six them. Seizures that recurred better did (seizure 86% vs. 23%). At final assessment, 54 (61%) 37 17 AEDs. more frequent younger age at time those shorter disease duration. Conclusions: Our results suggest is reasonable indication attempt discontinuation. subsequent control excellent, especially relapsed Younger duration seem affect long-term period.