Correlates of cognitive dysfunction in multiple sclerosis
作者： C. Heesen , K.H. Schulz , J. Fiehler , U. Von der Mark , C. Otte
DOI: 10.1016/J.BBI.2010.05.006
关键词: Internal medicine 、 Oncology 、 Working memory 、 Cohort 、 Depression (differential diagnoses) 、 Case-control study 、 Severity of illness 、 Psychology 、 Cognition 、 Endocrinology 、 Multiple sclerosis 、 Atrophy
摘要: Cognitive impairment is one of the most frequent symptoms in patients with multiple sclerosis (MS) but its underlying mechanisms are poorly understood. A number pathogenetic correlates have previously been proposed including psychosocial factors (such as depression and fatigue), inflammation, neurodegeneration, neuroendocrine dysregulation. However, these different systems never studied parallel their differential contributions to cognitive MS unknown. We a well-characterized cohort cognitively impaired (CI, n=25) preserved (CP, based on comprehensive neuropsychological testing battery, test hypothalamo-pituitary-adrenal axis functioning (dexamethasone-corticotropin-releasing hormone suppression test, Dex-CRH test) well peripheral blood MRI markers inflammatory activity. CI had significantly higher disability. In addition, showed levels fatigue depression. Fatigue was more closely associated measures attention while strongest correlations memory tests. Furthermore, percentage IFNγ-positive CD4+ CD8+ T cells modest processing speed working memory. inflammation or global atrophy were not function. Compared previous studies, exhibiting HPA hyperactivity very low no found conclude that main impairment, which show domain-specific associations
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