Disconnection of the hippocampus and amygdala associated with lesion load in relapsing–remitting multiple sclerosis: a structural and functional connectivity study

摘要: BACKGROUND AND PURPOSE Little is known about the functional and structural connectivity (FC SC) of hippocampus amygdala, which are two important structures involved in cognitive processes, or their involvement relapsing-remitting multiple sclerosis (RRMS). In this study, we aimed to examine white-matter (WM) tracts synchrony intrinsic neuronal activity outer regions connected with amygdala RRMS patients. PATIENTS METHODS Twenty-three patients 23 healthy subjects participated study. Diffusion tensor probabilistic tractography was used SC, FC correlation coefficient (FC-CC) combined strength (FCS), derived from resting-state magnetic resonance imaging FC, connection between other regions, correlations these connections clinical markers. RESULTS Compared subjects, showed significantly decreased SC increased FCS bilateral hippocampus, left amygdala. Their slightly FC-CC positively correlated WM tract damage right (ρ=0.57, P=0.005); an also A relationship observed lesion load alterations, including lg(N tracts) (ρ=-0.68, P<0.05), (ρ=-0.69, fractional anisotropy P<0.05) radial diffusivity (ρ=0.45, P<0.05). amygdale observed. CONCLUSION The concurrent demyelination-related disconnectivity suggest that functional-structural relationships require further investigation.