Disability worsening among persons with multiple sclerosis and depression: A Swedish cohort study

摘要: Objective Depression is common in multiple sclerosis (MS), but its impact on disability worsening has not yet been determined. We explored the risk of associated with depression a nationwide longitudinal cohort. Methods This retrospective cohort study used linked data from 3 Swedish registries: MS Register, National Patient and Prescribed Drug Register. Two incident cohorts were developed: 1 included all registered cases Registry (2001–2014) defined as ≥1 ICD-10 code for depression; 2 comprised (2005–2014) prescription filled an antidepressant. Cox regression models to compare reaching sustained milestone scores 3.0, 4.0, 6.0 Expanded Disability Status Scale (EDSS) between persons without depression. Results Cohort 5,875 cases; 502 (8.5%) had 3,817 1,289 (33.8%) prescribed Persons at significantly higher EDSS 6.0, hazard ratios 1.50 (95% confidence interval [CI] 1.20–1.87), 1.79 CI 1.40–2.29), 1.89 1.38–2.57), respectively. A similar increased among exposed antidepressants was observed, 1.37 1.18–1.60), 1.93 1.61–2.31), 1.86 1.45–2.40) Conclusion comorbid worsening. finding highlights need early recognition appropriate treatment MS.