Distinct translation regulation by two alternative 5 ' UTRs of a stress-responsive protein - dPrx I
作者： Chien-Wen Chen , Tzu-Yang Lin , Tsan-Chi Chen , Jyh-Lyh Juang
DOI: 10.1007/S11373-005-9013-2
关键词: Coding region 、 Gene isoform 、 Genetics 、 Translation (biology) 、 Untranslated region 、 Alternative splicing 、 Biology 、 Five prime untranslated region 、 Translational regulation 、 Internal ribosome entry site
摘要: Translation efficiency is often regulated in part by 5′-untranslated region (5′UTR). Sequence analysis of an evolutionarily conserved stress-responsive protein, Drosophila Peroxiredoxin I (dPrx I), found the transcript to have two alternative 5′UTRs that lead identical coding sequence: namely Ia and Ib. Although both isoforms coexisted cells, isoform appeared be dominant. Furthermore, reporter assay enhanced translation steady-state cells while Ib increased under oxidative stress. Together, our data suggest dPrx may involved a translational regulatory mechanism responds cellular
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