Fluorescent in-situ hybridization (FISH) as an aid to marker chromosome identification in prenatal diagnosis

作者: A. Amiel , M. Fejgin , Z. Appelman , I. Shapiro , E. Gaber

DOI: 10.1016/0028-2243(94)01964-9

关键词: KaryotypeFluorescence in situ hybridizationMolecular biologySmall supernumerary marker chromosomeCytogeneticsPrenatal diagnosisMarker chromosomeX chromosomeY chromosomeBiology

摘要: Five cases of supernumerary marker chromosomes were identified in prenatal diagnosis as derived from 18, X, and Y. One unexpected finding was a case where the PCR positive for SRY gene while fluorescence situ hybridization two X centromeres. In another with an newborn phenotypically normal. Two women fetal mar(18) mar(Xp) decided to terminate pregnancy. The fifth pregnancy had karyotype 46,XX,-15,+der(15)t(Y:15)(q11,23;p13). A normal girl born at term.

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