Sustained Intermittent Hypoxemia Induces Adiponectin Oligomers Redistribution and a Tissue-Specific Modulation of Adiponectin Receptor in Mice.

摘要: Introduction: Hypoxemia is a critical component of several respiratory diseases and known to be involved in the processes underlying co-morbidities associated such disorders, notably at cardiovascular level. Circulating level Adiponectin (Ad), as metabolic regulator cardio-protective hormone was previously suggested reduced by hypoxia but consequences variation are unclear. The evaluation specific effect hypoxemia on Ad forms receptors could improve understanding involvement axis hypoxemia-related diseases. Methods: Ad-pathway components were investigated murine model sustained intermittent (FiO2 10%, 8 h/day, 35 days). Results: Sustained (SIH) induced redistribution multimers favor HMW forms, without change total plasmatic Mice submitted also exhibited tissue-specific modification adiporeceptor (AdipoR) protein mRNA expression change. A decreased AdipoR2 abundance observed skeletal muscle heart whereas AdipoR1 only muscle. No liver regarding AdipoR. Lipid profile unchanged glucose tolerance increased hypoxemic mice. Conclusion: hypoxemia, per se, modify oligomerization state well AdipoR way. That suggests alteration Ad-dependant pathways pathological conditions SIH. Investigation therefore constitute useful complementary criteria for clustering patients with management co-morbidities, develop new therapeutic strategies.