KATP‐mediated Vasodilation is Impaired in Obese Zucker Rats
作者： Benjamin L. Hodnett , Lusha Xiang , Jennifer A. Dearman , Cory B. Carter , Robert L. Hester
DOI: 10.1080/10739680801942240
关键词: Potassium channel 、 Iloprost 、 Cromakalim 、 Skeletal muscle 、 Microcirculation 、 Glibenclamide 、 Internal medicine 、 Medicine 、 Vasodilation 、 Endocrinology 、 Phenylephrine
摘要: Objective: Skeletal muscle blood flow during exercise is impaired in obesity. We tested the hypothesis that attenuated vasodilation skeletal arterioles of obese Zucker rats (OZR) due to altered KATP channel-mediated vasodilation.Materials and Methods: channel function was determined isolated response opener cromakalim (0.1–10 μ M) normal myogenic tone α -adrenergic-mediated (0.1 M phenylephrine). The spinotrapezius prepared vasodilatory responses stimulation or iloprost (0.028–2.8 were observed before after application inhibitor, glibenclamide (10 M). Channel subunit expression by using western blot analyses.Results: Cromakalim concentration-response curves shifted OZR as compared lean controls. exhibited functional iloprost-induced Glibenclamide inhibited ilo...
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