Controlled induction of cirrhosis in the rat.

摘要: The production of experimental cirrhosis in the rat, most commonly by multiple doses carbon tetrachloride (CCl4), is a difficult process with low yield "cirrhosis" widely varied histology. This due to an unpredictable variation response rat liver CCl4, and lack reliable method monitoring rapidly changing damage each dose. A simple non-invasive described which daily body weight change weekly intragastric CCl4 has been shown empirically sufficiently reflect state as enable dose be calibrated previous death rate markedly reduced critical level can maintained. improved control over made it possible produce high (72%) standardized decompensated micronodular 8-10 CCl4. Under these weight-calibrated conditions this point determined non-invasively using visual grading ascites estimated during light halothane/oxygen anaesthesia relax abdominal musculature.