Interactions of cholecystokinin, β-endorphin, and their antagonists on passive avoidance behavior in rats

摘要: The effects of cholecystokinin octapeptide (CCK-8), tetrapeptide amide (CCK-4), beta-endorphin, proglumide, and naloxone on passive avoidance behavior were studied in rats. Intracerebroventricular (i.c.v.) injection beta-endorphin (1-10 micrograms) had no significant influence the latency response intact Also, (0.05-5 micrograms, i.c.v.) did not affect rats treated with electroconvulsive shock (ECS). preventive effect CCK-8 (0.1-1.0 ECS-induced amnesia was partly antagonized by (0.05-10 i.c.v.). Intraperitoneal (i.p.) mg/kg) could prevent amnesia, but continuous subcutaneous infusion this drug (2 mg/day, 7 days) completely abolished amnesia. Naloxone (1 10 mg/kg, i.p.) also induced proglumide prevented it when CCK-4 (5 results indicate facilitating action inhibitory memory, suggesting that endogenous opiate systems are involved some way memory processes.