Effects of cholecystokinin tetrapeptide and sulfated cholecystokinin octapeptide in rat models of anxiety.
作者： André Rex , Thomas Barth , Jörg-Peter Voigt , Annette M. Domeney , Heidrun Fink
DOI: 10.1016/0304-3940(94)90681-5
关键词: Sulfation 、 Anorectic 、 Endocrinology 、 Psychology 、 Tetrapeptide 、 Neuropeptide 、 Internal medicine 、 Elevated plus maze 、 CCK-4 、 Anxiety 、 Cholecystokinin
摘要: The effects of the acutely administered cholecystokinin (CCK) agonists CCK tetrapeptide (BOC-CCK-4) and sulfated octapeptide (CCK-8S) were examined in four animal models anxiety rats. In elevated plus maze, BOC-CCK-4 reduced time spent open arms number entries into arms. but not anorectic acting CCK-8S increased suppression feeding a conflict paradigm based on novelty suppressed hungry two-compartment black-and-white box, decreased locomotor activity white compartment. ultrasound vocalization test, using rat pups separated from mother, distress calls. No evidence was found for inducing anxiety-like behaviour by CCK-8S.
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