Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins

摘要: The maintenance of protein solubility is a fundamental aspect cellular homeostasis because aggregation associated with wide variety human diseases. Numerous proteins unrelated in sequence and structure, however, can misfold aggregate, widespread occur living systems under stress or aging. A crucial question this context why only certain appear to aggregate readily in vivo, whereas others do not. We identify here the most vulnerable as those whose concentrations are high relative their solubilities. find that these supersaturated represent metastable subproteome involved pathological during aging overrepresented biochemical processes neurodegenerative disorders. Consequently, such become dysfunctional when ability keep intrinsically soluble compromised. Thus, simultaneous analysis abundance rationalize diverse pathologies linked diseases