摘要: It is well established that amyloid fibril solubility protein specific, but how depends on the interactions between building blocks not clear. Here we use a simple model and perform Monte Carlo simulations to directly measure of fibrils as function interaction blocks. Our confirms thickness relationship can be described by analytical formula. The results presented in this study reveal general rules side-chain–side-chain interactions, backbone hydrogen bonding, temperature affect solubility, which might prove powerful tool design with desired aggregation properties general.
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