Confounding the Paradigm: Peculiarities of Amyloid Fibril Nucleation
作者： Dimo Kashchiev , Raffaela Cabriolu , Stefan Auer
DOI: 10.1021/JA311228D
关键词: Crystallography 、 Polymerization 、 Amyloid fibril 、 Nucleation 、 Kinetic Monte Carlo 、 Chemistry 、 Chemical physics 、 Amyloid 、 Fibril
摘要: Fibrils of amyloid proteins are currently great interest because their involvement in various amyloid-related diseases and nanotechnological products. In a recent kinetic Monte Carlo simulation study (Cabriolu, R.; Kashchiev, D.; Auer, S. J. Chem. Phys.2012, 137, 204903), we found that our data for the rate fibril nucleation occurring by direct polymerization monomeric protein could not be described adequately theory. It turned out process occurred peculiar way, thus confounding paradigm demanding new theoretical treatment. present study, reconsider approach to fibrils derive expressions stationary process. As these provide remarkably good description data, using them propose dependence amyloid-β40 on concentration solution. This dependence...
acs.org
sci-hub.se 参考文章(29)
Frank Ferrone, Analysis of protein aggregation kinetics. Methods in Enzymology. ,vol. 309, pp. 256- 274 ,(1999) , 10.1016/S0076-6879(99)09019-9
Stefan Auer, Dimo Kashchiev, Phase diagram of alpha-helical and beta-sheet forming peptides. Physical Review Letters. ,vol. 104, pp. 168105- ,(2010) , 10.1103/PHYSREVLETT.104.168105
Frank A. Ferrone, Nucleation: the connections between equilibrium and kinetic behavior. Methods in Enzymology. ,vol. 412, pp. 285- 299 ,(2006) , 10.1016/S0076-6879(06)12017-0
Frank A. Ferrone, James Hofrichter, William A. Eaton, Kinetics of sickle hemoglobin polymerization: II. A double nucleation mechanism Journal of Molecular Biology. ,vol. 183, pp. 611- 631 ,(1985) , 10.1016/0022-2836(85)90175-5
Raffaela Cabriolu, Stefan Auer, Amyloid Fibrillation Kinetics: Insight from Atomistic Nucleation Theory Journal of Molecular Biology. ,vol. 411, pp. 275- 285 ,(2011) , 10.1016/J.JMB.2011.05.032
S. Linse, C. Cabaleiro-Lago, W.-F. Xue, I. Lynch, S. Lindman, E. Thulin, S. E. Radford, K. A. Dawson, Nucleation of protein fibrillation by nanoparticles Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 8691- 8696 ,(2007) , 10.1073/PNAS.0701250104
Rosa Crespo, Fernando A. Rocha, Ana M. Damas, Pedro M. Martins, A Generic Crystallization-like Model That Describes the Kinetics of Amyloid Fibril Formation Journal of Biological Chemistry. ,vol. 287, pp. 30585- 30594 ,(2012) , 10.1074/JBC.M112.375345
Raffaela Cabriolu, Dimo Kashchiev, Stefan Auer, Breakdown of nucleation theory for crystals with strongly anisotropic interactions between molecules Journal of Chemical Physics. ,vol. 137, pp. 204903- 204903 ,(2012) , 10.1063/1.4767531
Stefan Auer, Phase diagram of polypeptide chains. Journal of Chemical Physics. ,vol. 135, pp. 175103- ,(2011) , 10.1063/1.3656764
Hung D. Nguyen, Carol K. Hall, Spontaneous Fibril Formation by Polyalanines; Discontinuous Molecular Dynamics Simulations Journal of the American Chemical Society. ,vol. 128, pp. 1890- 1901 ,(2006) , 10.1021/JA0539140