Environmental Hygiene and Risk of Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis.
作者： Aurada Cholapranee , Ashwin N. Ananthakrishnan
DOI: 10.1097/MIB.0000000000000852
关键词: Crohn's disease 、 Environmental exposure 、 Medicine 、 Hygiene 、 Hygiene hypothesis 、 Meta-analysis 、 Confidence interval 、 Odds ratio 、 Cohort 、 Internal medicine
摘要: BACKGROUND According to the hygiene hypothesis, individuals raised in a sanitary environment have higher risk of developing inflammatory bowel diseases (IBD). However, results been inconsistent. We conducted this systematic review factors related environmental and IBD, Crohn's disease (CD) ulcerative colitis (UC). METHODS A search was performed on MEDLINE between 1980 2015 identify studies association IBD contact with pets farm animals, number siblings, bedroom sharing childhood, access personal toilet hot water. Random- or fixed-effect meta-analyses were performed, analysis further stratified based ethnicity included cohort. RESULTS total 29 relevant included. Having pet (odds ratio [OR], 0.76; 95% confidence interval [CI], 0.63-0.88) animals inversely associated (OR, 0.45; CI, 0.31-0.60). strength statistically stronger non-white cohorts 0.27; 0.02-0.53) than white 0.55; 0.45-0.65) (P = 0.028). Access 0.71; 0.56-0.85) water 0.67; 0.44-0.89) UC populations but not whites. more 2 siblings CD. CONCLUSIONS Several pertaining reduced are IBD. underlying influences susceptibility effect these factors.
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