Genes and regulatory pathways involved in persistence of dormant micro-tumors.

摘要: Micro-tumors can remain dormant for prolonged periods of time before they switch and enter the rapid growth phase. This initial stage in tumor progression is clearly understudied. In spite high prevalence, significant clinical implications increased interest by research community, dormancy still poorly understood. The topic also suffers from a lack definition an agreed upon terminology to describe it. Additionally, number reproducible experimental models available studying indolence human micro-tumors quite limited. Here, we development general class vivo indolent tumors how these be used elucidate molecular cellular mechanisms involved regulation dormancy. consist cell lines that form microscopic cancerous lesions mice. Although contain viable fully malignant cancer cells, do not expand size but occult until eventually spontaneously become fast-growing tumors. Consistent with Judah Folkman’s vision will acquire ability recruit new functional blood vessels, period associated impaired angiogenic capacity. Such dissecting host tumor-derived regulatory Understanding process which overcome constraints emerge dormancy, resuming expansion, may provide insights into novel strategies prolong state or block formation early stages, are physically detected symptomatic.