Dormant tumor cells as a therapeutic target?

作者: Bruno Quesnel

DOI: 10.1016/J.CANLET.2008.02.055

关键词:

摘要: Tumor dormancy is characterised by the persistence of residual tumor cells for long periods. Recurrence from minimal disease a major cause cancer death. Thus, understanding how become and remain dormant, may lead to new strategies prevent relapse. Evidence has emerged that balance exists between host dormant cells. Cross-talk their micro-environment, angiogenesis, anti-tumor immune response participate in control have several mechanisms maintaining equilibrium, escape, including expression immuno-regulatory molecules (e.g., increased B7.1 B7-H1); epigenetic modifications silencing SOCS1 gene, de-regulating JAK/STAT pathway); autocrine loops. These findings offer opportunities design specific treatments, modify favor response.

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